G.W. Gross - C.V.

Pertinent Publications

*arranged in chronological order

Gross, G.W., Rieske, E., Kreutzberg, G.W. and Meyer, A. (l977). A new fixed-array multimicroelectrode system designed for longterm monitoring of extracellular single unit neuronal activity in vitro. Neurosci. Lett. 6: 101-105.

Gross, G.W. (l979). Simultaneous single unit recording in vitro with a photoetched laser deinsulated gold multi-microelectrode surface. IEEEE Trans. Biomed. Eng. BME-26: 273-279.

Gross, G.W., Williams, A.N. and Lucas, J.H. (l982). Recording of spontaneous activity with photoetched microelectrode surfaces from mouse spinal neurons in culture. J. Neurosci. Meth. 5: 13-22.

Gross, G.W. and Lucas, J.H. (1982). Long-term monitoring of spontaneous single unit activity from neuronal monolayer networks cultured on photoetched multielectrode surfaces. J. Electrophys. Tech. 9: 55-69.

Gross, G.W., Lucas, J.H., and Higgins, L.M. (1983). Laser microbeam surgery: ultrastructural changes associated with neurite transection in culture. J. Neuroscience 3: 1979-1993.

Kirkpatrick. J.B., Higgins, M.L., Lucas, J.H. and Gross, G.W. (1985). Neural trauma simulation by laser in vitro. J. Neuropath and Exp. Neurol. 44: 268-284.

Lucas, J.H., Kirkpatrick, J.B. and Gross, G.W. (l985). A photoetched matrix for cell relocation in culture and histology. J. Neurosci. Meth. 14: 211-219.

Hightower, M.H. and Gross, G.W. (l985). A combined Bodian-Nissl stain for improved network analysis in neuronal cell culture. Stain Technol. 60: 315-320.

Gross, G.W., Wen, W. and Lin, J. (l985). Transparent indium-tin oxide patterns for extracellular, multisite recording in neuronal cultures. J. Neurosci. Meth. 15: 243-252.

Lucas, J.H., Gross, G.W., Emery, D.G. and Gardner, C.R. (l985). Neuronal survival after dendrite transection close to the perikaryon. Central Nervous System Trauma. 2: 231-255.

Lucas, J.H., Czisny, L.E. and Gross, G.W. (l986). Adhesion of cultured mammalian CNS neurons to flame-modified hydrophobic surfaces. In Vitro. 22: 37-43.

Droge, M.H., Gross, G.W., Hightower, M.H. and Czisny, L.E. (l986). Multielectrode analysis of coordinated, rhythmic bursting in cultured CNS monolayer networks. J. Neuroscience 6: 1583-1592.

Gross, G.W. and Higgins, M.L. (l987). Cytoplasmic damage gradients in dendrites after transection lesions. Exp. Brain Res. 67: 52-60.

Emery, D.G., Lucas, J.H., and Gross, G.W. (l987). The sequence of ultrastructural changes in cultured neurons after dendrite transection. Exp. Brain Res. 67: 41-51.

Gross, G.W. and Hightower, M.H. (l987). An approach to the determination of network properties in mammalian neuronal monolayer cultures. Proceedings of the First IEEE Conference on Synthetic Microstructures in Biological Research (M.C. Peckerar, S.A. Shamma, and R.J. Wyatt, eds.) Naval Research Lab Press.

Gross, G.W. and Hightower, M.H. (1987) Multielectrode investigations of network properties in neural monolayer cultures. Proc. of the 6th Southern Biomed. Eng. Conf., MacGregor and Werner, Washington, D.C. pp. 212-217.

Kowalski, J.M., Ansari, A., Prueitt, P., Dawes, R., and Gross, G.W. (1988) Coupled rotators as a model for spontaneous activity in neural networks. Proc. 1988 MIDCON Tech. Conf., Dallas. pp 11-13.

Kowalski, J.M., Ansari, A., Prueitt, P., Dawes, R., and Gross, G.W. (1988) On synchronization and phase locking in strongly coupled systems of planar rotators. Complex Systems 2: 441-462.

Turkle-Huslig, T., Carter, S.J., Howard, L., and Gross, G.W. (1989) Stability of impedance characteristics at the microelectrode-saline interface. Proc. of the Ann. IEEE Int. Conf. in Medicine and Biology Society, Seattle, WA., pp. 1427-1428.

Vithalani, P.V., Abuzaid, M.A., Gosney, W.M., Howard, L.L., and Gross, G.W. (1989) A sixteen-channel CMOS analog preamplifier chip for monitoring and stimulating action potentials of cultured neurons. Proc. 8th Southern Biomed. Eng. Conf., Richmond, VA. pp 118-121.

Gross, G.W., Kowalski, J.M., and Golden, D. (1990) On the behavior and significance of random neuronal networks. Proceedings of the International Joint Conference on Neural Networks, Washington, Vol 1, pp 86-89.

Kowalski, J.M. and Gross, G.W. (1990) Coupled relaxational oscillators as a model of spon-taneous activity in neuronal networks. Proceedings of the International Joint Conf. on Neural Networks, Paris, Vol 1, pp 488-491.

Kowalski, J.M., Albert, G.L., and Gross, G.W. (1990) On the asymptotically synchronous chaotic orbits in systems of excitable elements. Physical Review A, 42: 6260-6263.

Gross, G.W. and Kowalski, J.M. (1991) Experimental and theoretical analyses of random network dynamics. In: Neural Networks, Concepts, Application and Implementation, Vol. 4 (Antognetti and Milutinovic, eds), Prentice Hall, N.J., pp 47-110.

Abuzaid, M.A., Vithalani, P.V., Howard, L., Gosney, W.M., and Gross, G.W. (1991) A VLSI peripheral system for monitoring and stimulating action potentials of cultured neurons. Proc. of the 1st Great Lakes Symp. on VLSI, Kalamazoo, MI., pp. 170-173.

Gross, G.W., Rhoades, B.K., and Jordan, R.J. (1992) Neuronal networks for biochemical sensing. Sensors and Actuators 6: 1-8.

Kowalski, J.M., Albert, G.L., Rhoades, B.K., and Gross, G.W. (1992) Correlated spontaneous activity in cultured neuronal networks as possible manifestations of synchronized chaos. In: Proceedings of 1st Conference on Experimental Chaos, Arlington VA. (S. Vohara, M. Sapano, M. Schlesinger, L. Pecora, and W. Ditto eds.), World Scientific, Singapore; pp. 213-218.

Kowalski, J.M., Albert, G.L., Rhoades, B.K., and Gross, G.W. (1992) Neuronal networks with spontaneous, correlated bursting activity: theory and simulations. Neural Networks 5: 805-822.

Tai, J-D., Gosney, W. M., Howard, LL., and Gross, G.W. (1992) An algorithm and its implementation for neural spike-burst-pattern recognition. Proceedings of the '92 Conference on Artificial Neural Networks in Engineering. Vol 2, pp 457-462; ASME Press, N.Y.

Tai, J-D., Gosney, W. M., Howard, LL., and Gross, G.W. (1992) Real-time neural pulse pattern feature extraction and recognition. 35th Midwest Symposium on Circuits and Systems, Vol. 2, pp 1527-1529.

Gross, G.W., Rhoades, B.K., and Kowalski, J.M. (1993) Dynamics of burst patterns generated by monolayer networks in culture. In: Neurobionics (H.W. Bothe, M. Samii and R. Eckmiller, eds) Elsevier, Amsterdam , pp.89-121.

Gross, G.W., Rhoades, B.K., Reust, D.L., and Schwalm, F.U. (1993) Stimulation of monolayer networks in culture through thin film indium-tin oxide recording electrodes. J. Neurosci. Meth. 50: 131-143.

Gross, G.W. (1994) Internal dynamics of randomized mammalian neuronal networks in culture. In: Enabling Technologies for Cultured Neural Networks (D.A. Stenger and T.M. McKenna, eds), Academic Press, N.Y. pp 277-317.

Tam, D.C. and Gross, G.W. (1994) Extraction of dynamical changes in neuronal network circuitries using multi-unit spike train analysis. In: Enabling Technologies for Cultured Neural Networks (D.A. Stenger and T.M. McKenna, eds), Academic Press, N.Y.

Rhoades, B.K. and Gross, G.W. (1994) Potassium and calcium channel dependence of bursting in cultured neuronal networks. Brain Research 643: 310-318.

Gross, G.W. and Schwalm, F.U. (1994) A closed chamber for long-term electrophysiological and microscopical monitoring of monolayer neuronal networks. J. Neuroscience Methods 52: 73-85.

Gross, G.W. and Tam, D.C. (1994) Pre-conditional correlation between neurons in cultured networks. Proceedings of the 1994 World Congress on Neural Networks, San Diego; Vol. 2, pp. 786-791.

Tam, D.C. and Gross, G.W. (1994) Post-conditional correlation between neurons in cultured neuronal networks. Proceedings of the 1994 World Congress on Neural Networks, San Diego; Vol. 2, pp. 792-797.

Gross, G.W., Azzazy, H.M.E., Wu, M-C, and Rhoades, B.K.(1995) The use of neuronal networks on multielectrode arrays as biosensors. Biososensors and Bioelectronics 10: 553-567.

Azzazy, H.M.E., Hong, K., Wu, M-C, and Gross, G.W. (1995) Interaction of cationic liposomes with cells of electrically active neuronal networks in culture. Brain Research 695: 231-236.

Rhoades, B.K., Weil, J.C., Kowalski, J.M., and Gross, G.W. (1996) Distribution-free graphical and statistical analysis of serial dependence in neuronal spike trains. J. Neurosci. Meth. 64: 25-37.

Gopal, K.V. and Gross, G.W. (1996) Auditory cortical neurons in vitro: Cell culture and multichannel extracellular recording. Acta Otolaryngologica, 116: 690-696.

Gopal, K.V. and Gross, G.W. (1996) Auditory cortical neurons in vitro: Initial pharmacological studies. Acta Otolaryngologica, 116: 697-704.

Gross, G.W., Harsch, A., Rhoades, B.K., and Göpel, W. (1997) Odor, drug, and toxin analysis with neuronal networks in vitro: extracellular array recording of network responses. Biososensors & Bioelectronics 12: 373-393.

Gross, G.W., Norton, S., Gopal, K., Schiffmann, D., and Gramowski, A. (1997) Nerve cell network in vitro: Applications to neurotoxicology, drug development, and biosensors. In: The Neuro-Electronic Interface. Cellular Engineering 2: 138-147.

Bogdan, M., Harsch, A., Gross, G.W., Göpel, W., and Rosenstiel, W. (1997) Processing of nerve cell signal recordings from cultured networks using artificial neural nets. 1997 Proceedings of the IASTED on Artificial Intelligence and Soft Computing, Banff, Canada.

Gross, G.W. and Kowalski, J.M. (1998) Emergent dynamical properties of biological neuronal ensembles and their theoretical interpretation and significance. AIP Conf. Proc. 437: 577-594.

Calderon, J.G., Harsch, A., Gross, G.W., and Timmons, R. (1998) Stability of plasma polymerized allylamine films towards sterilization via autoclaving. J. of Biomed. Mater. Res. 42: 597-603.

Gross, G.W. (1998) Emergent Properties of Self-Organizing Nerve Cell Ensembles in Culture. Proc. of the 4th Internat. Conf. on Intelligent Materials, Tokyo, Japan. pp 326-329.

Gross, G.W., Kowalski, J.M. and Rhoades, B.K. (1999) Spontaneous and evoked oscillations in cultured neuronal networks. In: Oscillations in Neural Systems (D. Levine, V. Brown, T. Shirey, eds) Erlbaum Assoc., N.Y.pp 3-29.

Harsch, A., Calderon, J., Timmons, R. B, and Gross, G.W. (2000) Pulsed plasma deposition of allylamine on polysiloxane: a stable surface for neuronal cell adhesion. J. Neuroscience Methods 98: 135-144.

Gramowski, A., Schiffmann, D., and Gross, G.W. (2000) Quantification of acute neurotoxic effects of trimethyltin using neuronal networks cultured on microelectrode arrays. J. NeuroToxicology 21: 331-342.

Gross, G.W. and Kowalksi, J.M. (2000) Origins of activity patterns in self-organizing neuronal networks in vitro. Journal of Intelligent Material Systems and Structures 10: 558-564.

Morefield, S. I., Keefer, E.W., Chapman, K. D., and Gross, G.W. (2000) Drug evaluations using neuronal networks on microelectrode arrays: characteristic effects of cannabinoid agonists anandamide and methanadamide on cortical and spinal cultures. Biosensors and Bioelectronics 15: 383-396.

Keefer, E.W., Norton, S.J., Boyle, N.A.J., Talesa, V., and Gross, G.W. (2001) Acute toxicity screening of novel AChE inhibitors using neuronal networks on microelectrode arrays. NeuroToxicology 22 (1): 3-12.

Stenger, D.A., Gross. G.W., Keefer, E.K., Shaffer, K.M., Andreadis, J.D., Wu Ma, and Pancrazio, J.J. (2001) Detection of physiologically active compounds using cell-based biosensors. Trends in Biotechnology 19: 304-309.

Pancrazio, J.J., Keefer, E.W., Stenger, D.A., and Gross, G.W. (2001) Neurophysiologic evaluation of chemical agent hydrolysis products on cortical neurons in vitro. NeuroToxicology 22:393-400.

Keefer, E.K., Gramowski, A., Stenger, D.A., Pancrazio, J.J., and Gross, G.W. (2001) Characterization of acute neurotoxic effects of trimethylolpropane phosphate via neuronal network biosensors. Biosensors and Bioelectronics 16: 513-525.

Keefer, E.W., Gramowski, A., and Gross, G.W. (2001) NMDA receptor dependent periodic oscillations in cultured spinal cord networks. J. Neurophysiol. 86: 3030-3042.

Pancrazio JJ, Gray SA, Shubin YS, Cuttino DS, Shaffer KM, Eisemann K, Curran A, Zim B, Gross GW, O'Shaughnessy TJ. (2003) A portable microelectrode array recording system incorporating cultured neuronal networks for neurotoxin detection. Biosensors & Bioelectronics (in press).

O_Shaughnessy, T. J., Zim, B., Wu Ma , Shaffer, K. M., Stenger, D. A. Zamani, K., Gross, G. W., Pancrazio, J. J.(2003) Acute neuropharmacologic action of chloroquine on cortical neurons in vitro.
Brain Research 959 (2003) 280_286 .

Xia, Y., Gopal, K.V., and Gross, G.W. (2003) Differential acute effects of fluoxetine on frontal and auditory cortex networks in vitro. Brain Research, 973: 151-160.

Xia, Y. and Gross, G.W. (2003) Histiotypic electrophysiological responses of cultured neuronal networks to ethanol. Alcohol 30: 167-174.

Pancrazio, J.J., Gray, S.A., Shubin, Y.S., Kulagina, N., Cuttino, D.S., Shaffer, K.M., Eisemann, K., Curran, A, Zim, B, Gross, G.W., and O'Shaughnessy, T.J. (2003) A portable microelectrode array recording system incorporating cultured neuronal networks for neurotoxin detection. Biosensors and Bioelectronics 18/11: 1339-1347.

Ignaccolo, M., Grigolini P., and Gross, G.W. (2003) Towards the timely detection of toxicants. Chaos, Solitons and Fractals 20: 87-93.

Selinger, J., Pancrazio, J.J., and Gross, G.W. (2004) Measuring synchronization in neuronal networks for biosensor applications. Biosensors and Bioelectronics: 675-683.

Gramowski, A, Juegelt, K., Weiss, D.G., and Gross, G.W. (2004) Substance identification by quantitative characterization of oscillatory activity in murine spinal cord networks on microelectrode arrays. European J. Neurosci., 19: 2815-2825.

Gopal, K.V. and Gross, G.W. (2004) Unique responses of auditory cortex networks in vitro to low concentrations of quinine. Hearing Research 192: 10-22.

Turnbull, L. and Gross, G.W. (2005) The string method of burst identification in neuronal spike trains. J. Neurosci. Meth. 145: 23-35.

Gross, G.W., Dian, E., Keefer, E.W., Gramowski, A., and Stuewe, S. (2005) Long-term functional contact between nerve cell networks and microelectrode arrays. In (Berger, T. and Glanzman, D., eds.) Toward Replacement Parts for the Brain. The MIT Press, pp 177-203.

Gross, G.W and Gopal, K.V. (2006) Emerging histiotypic properties of cultured neuronal networks. In: M. Taketani and M. Baudry (eds) Advances in Network Electrophysiology using Multi-Electrode Arrays. Springer, pp 193-214.

Gross, G.W. and Pancrazio, J.P.P. (2006) Neuronal Network Biosensors. In: Smart Biosensor Technology (G.K. Knopf and A.S. Bassi, eds), Marcel Dekker, Inc.; Invited book chapter, (in press).

Gross, G.W., Rijal-Oli, S., Jones, V, Hollmuller, D., and Karg, M. (2006) High throughput microelectrode array platforms for quantitative pharmacology and toxicology. Proceedings of MEA 2006, BIOPRO, Baden-Wuerttemberg.

Gross, G.W., Parviz, M. Ham, M., and Karg, M. (2006) Nerve Cell Networks on Microelectrode Arrays: High Throughput Platforms for Pharmacology, Toxicology, and Neuroinformatics. Proceedings of Medical Electronics Conference, 2006: Silicone Meets Medicine. Munich, Germany.

Shafer, T.J., Rijal-Oli, S. and Gross, G.W. (2006) Deltamethrin and permethrin decrease spontaneous activity in neuronal networks in vitro. Proceedings of MEA 2006, BIOPRO, Baden-Wuerttemberg.

Meyer, J.F. and Gross, G.W. (2006) Magnetic stimulation and depression of non-homogenous networks in primary neuronal cell cultures. Proceedings of MEA 2006, BIOPRO, Baden-Wuerttemberg.

Parviz, M. and Gross, G.W. (2006) Quantification of zinc toxicity using neuronal networks on microelectrode arrays.NeuroToxicology (2006), doi:10.1016/j.neuro.2006.11.006

Bettencourt L.M, Stephens, G.J., Ham, M., and Gross, G.W. (2007) The Functional structure of cortical neuronal networks grown in vitro. Physical Review E. (021915).